Table 1.
Effect of allantoin on body weight and haematological parameters in cisplatin‐treated rats
| Parameters | Group 1 Normal control | Group 2 Cisplatin (2 mg/kg ip) | Group 3 Cisplatin (2 mg/kg ip) + allantoin (200 mg/kg po) | Group 4 Cisplatin (2 mg/kg ip) + allantoin (400 mg/kg po) |
|---|---|---|---|---|
| Body weight (g) | 269.166 ± 11.432 | 212.833 ± 15.413 | 217.833 ± 7.516 | 219.333 ± 18.957 |
| WBC count (×103/µl) | 6.733 ± 0.313** | 5.133 ± 0.301 | 5.483 ± 0.291 | 4.916 ± 0.257 |
| RBC count (×106/µl) | 6.836 ± 0.111*** | 4.285 ± 0.371 | 6.008 ± 0.363*** | 5.936 ± 0.292** |
| Haemoglobin (g/dL) | 13.083 ± 0.327*** | 8.216 ± 0.703 | 10.317 ± 0.241* | 10.117 ± 0.509* |
| Platelet count (×103/µl) | 538.833 ± 20.956*** | 403.333 ± 25.489 | 500.000 ± 6.875* | 541.666 ± 36.137*** |
Values are expressed as means ± SEM (n = 6). The data were statistically analyzed by one‐way.
ANOVA followed by Dunnet's multiple comparison test.
*P < 0.05 was considered as significant, **P < 0.01 was considered as highly significant and ***P < 0.001 was considered as very highly significant when compared with the cisplatin control group.