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. 2019 Jun 25;11:5821–5834. doi: 10.2147/CMAR.S198615

Figure 8.

Figure 8

miR-548b overexpression suppresses tumor growth of hepatocellular carcinoma (HCC) cells in vivo. (A) Photographs of tumor xenografts derived from Hep3B cells transfected with miR-548b mimics or negative control (NC) mimics. (B) The tumor volume in the miR-548b overexpression group was notably smaller than that in the NC mimics group. *P<0.05 as compared with NC mimics. (C) The weight of tumor xenografts in groups “miR-548b mimics” and “NC mimics” was quantitated. *P<0.05 in comparison with NC mimics. (D) Reverse-transcription quantitative PCR analysis was performed to determine miR-548b expression in the tumor xenografts derived from Hep3B cells transfected with miR-548b mimics or NC mimics. *P<0.05 relative to NC mimics. (E) H&E staining was utilized to determine whether the tumor xenografts were real tumor tissues. (F) Western blotting was carried out to measure the HMGB1, p-PI3K, PI3K, p-AKT, and AKT amounts in the tumors excised from the mice.