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IGH clonality analysis of the patient’s tumors. (A) Monoclonal Vн-FR2-Jн rearrangements and Vн3 usage. (B) Sanger sequencing of the rearranged regions showing hypermutated IGHV 3-53 sequences and ongoing mutations in both lymphomas: FL (91.9 % homology with the germline) and PCNSL (82.2% homology). Asterisks indicate identity with germline. FL: follicular lymphoma; PCNSL: primary central nervous system lymphoma.
