Figure 5.

Inhibition of food intake is compromised in LepRb^G506S/G506Smice, but energy expenditure is comparable to lean littermates. (A) Food intake during 24 hours following 2 hours starvation, starting from 12 hours of dark. Values represent mean and standard error, stars indicate comparison to controls. (B) Respiratory exchange ratio and average of 12 hours dark or light. (C) Energy expenditure and sum of 12 hours dark or light. (D) Energy expenditure after 2 hours fasting and sum of 12 hours dark or light. (B–D) Dots represent mean; bars represent mean and standard deviation. n = 4 or 6/group. *, P < 0.05; **, P < 0.01; ***, P < 0.001, ****, P < 0.0001.