Summary of findings 10. Procedures: Doffing with Hypochlorite versus doffing with Alcohol‐based glove sanitizer.
| Doffing with Hypochlorite compared to doffing with Alcohol‐based glove sanitizer for preventing highly infectious diseases due to exposure to contaminated body fluids in healthcare staff | ||||||
| Patient or population: Preventing highly infectious diseases due to exposure to contaminated body fluids in healthcare staff Setting: Intervention: Doffing with Hypochlorite Comparison: Doffing with Alcohol‐based glove sanitizer | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Risk with doffing with Alcohol‐based glove sanitizer | Risk with Doffing with Hypochlorite | |||||
| Contamination MS2 | Study population | RR 4.00 (0.47 to 34.24) | 15 (1 observational study) | ⊕⊝⊝⊝ VERY LOW 1 2 3 | ||
| 100 per 1,000 | 400 per 1,000 (47 to 1,000) | |||||
| Contamination Ph6 | Study population | not estimable | 15 (1 observational study) | ‐ | ||
| 0 per 1,000 | 0 per 1,000 (0 to 0) | |||||
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; OR: Odds ratio; | ||||||
| GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | ||||||
1 Allocation to intervention was based on belonging to last five participants, which is an unclear selection procedure and so we downgraded with one level because of study limitations.
2 This is a simulation study so we downgraded with one level because of indirectness.
3 The study had a small number of participants and so we downgraded with one level because of imprecision.