Houlihan 2017.
Methods | Retrospective cohort study Invitations to participate were sent to individuals known to the authors, and through organisations supporting EMT deployment involving UK‐based staff, including non‐governmental organisations (NGOs), UK government‐affiliated institutions, and the London School of Hygiene & Tropical Medicine (LSHTM). The participants filled in a questionnaire with information about PPE use. They then underwent a blood test to assess their antibody status. The researchers assessed the participants' risk of being exposed to EVD based on an independent algorithm. |
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Participants | N = 300 Individuals who returned to the UK or Ireland after responding to the West African EVD epidemic completed the survey. Of these N = 268 returned material for IgG assessment (median age 36 y range 30‐45 y;57% female; 35% lab staff, 26% physicians, 20% nurses, 19% other) In addition, there were N = 53 non‐exposed control participants included who had not left the UK (median age 35 y range 31‐40 y; 66% female) | |
Interventions | There were 2 interventions that were of interest. (1) PPE removal with or without chlorine spray, (2) PPE removal with and without assistance. However, almost all clinical staff had used both interventions as compared to laboratory staff which had not used them. Because there was also a big difference in the likelihood of exposure between these two occupational groups, the effect of protection of these measures could therefore not be analysed. | |
Outcomes | Level of IgG antibody against Ebola Virus as an indicator of infection . | |
Notes | Country: UK; Funding by Wellcome Trust: Enhancing Research Activity in Epidemic Situations. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript; one author has received funding from the Wellcome Trust via the University of Liverpool and also received non‐financial support from NHSBT, as part of the Convalescent Plasma Study. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Confounding NRS | Low risk | Differences related to: 1. prior experience with PPE‐ No 2. healthcare qualification or education of HCW‐No (clinical, lab or other role) 3. age‐No 4. sex‐ No 5. ambient temperatures‐ No (all restricted to Africa) 6. stressful activities‐ Yes (work roles varied depending on qualifications) |
Selection Bias NRS | High risk | Sample based on snowball sampling |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | Participants were not aware of exposure status when they reported their exposures. |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Researchers knew who was rated as 'high risk' but objective outcome measure. Therefore unlikely that it has been influenced |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Convenience sample; from sample 10.7% did not react |
Selective reporting (reporting bias) | Unclear risk | No protocol provided |
Other bias | Low risk | No other sources of bias detected |