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. 2019 Jun 18;18(2):1458–1464. doi: 10.3892/etm.2019.7689

Figure 3.

Figure 3.

miR-876-5p targets TFAP2A in breast cancer cells. (A) Predicted binding site for miR-876-5p in the 3′-UTR of TFAP2A by bioinformatics analysis. (B) Luciferase reporter assay revealed that miR-876-5p upregulation suppressed the activity of TFAP2A WT reporter but not the MUT one. (C) Reverse transcription-quantitative PCR and (D) western blot analysis revealed that TFAP2A mRNA and protein levels were suppressed by miR-876-5p mimics. *P<0.05 vs. NC-miRNA group. miR, microRNA; TFAP2A, transcription factor AP-2 α; WT, wild-type; MUT, mutant; NC, negative control; UTR, untranslated region.