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. 2019 Jun 14;18(2):1449–1457. doi: 10.3892/etm.2019.7676

Figure 5.

Figure 5.

Recovery of IGF-1R expression reverses the inhibitory effects of miR-877 overexpression on the proliferation and invasion of H460 and A549 cells. (A) Protein expression levels of IGF-1R were detected by western blot analysis in H460 and A549 cells following co-transfection with miR-877 mimics and pc-IGF-1R or empty pcDNA3.1 plasmid. (B) Cellular proliferation of H460 and A549 cells was examined using a CCK-8 assay. (C) Transwell invasion assay to examine the invasive capacity of aforementioned cells (magnification, ×200). *P<0.05 and **P<0.05 vs. miR-NC + pcDNA3.1; #P<0.05, vs. miR-877 mimics + pcDNA3.1. CCK-8, Cell Counting kit-8; IGF-1R, insulin-like growth factor 1 receptor; miR-877, microRNA-877; miR-NC, microRNA mimics negative control; OD, optical density.