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. 2019 Jun 14;18(2):1440–1448. doi: 10.3892/etm.2019.7675

Figure 5.

Figure 5.

FGFR2 overexpression rescues miR-889-mediated suppression of cervical cancer cell viability and invasion. (A) pc-FGFR2 or empty pcDNA3.1 plasmid was transfected into HeLa and SiHa cells, and FGFR2 protein expression was determined using western blot analysis. *P<0.05 vs. pcDNA3.1. (B) pc-FGFR2 or pcDNA3.1 was co-transfected with miR-889 mimic in HeLa and SiHa cells. Western blot analysis was used to measure FGFR2 protein expression 72 h following transfection. *P<0.05 vs. miR-NC; #P<0.05 vs. miR-889 mimic + pcDNA3.1. (C) Cell viability and (D) invasive ability of HeLa and SiHa cells were assessed using Cell Counting Kit-8 and Matrigel invasion assays, respectively. *P<0.05 vs. miR-NC; #P<0.05 vs. miR-889 mimic + pcDNA3.1. FGFR2, fibroblast growth factor receptor 2; miR, microRNA; NC, negative control; pc-FGFR2, pcDNA3.1-FGFR2; siRNA, small interfering RNA.