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BAP1 regulated the transcription of Snail through deubiquitinating H2A. (A) Quantitative real-time PCR quantifying the mRNA level of EMT markers, n = 3. (B) ChIP analysis showed that H2Aub (Lys119) modification was highly enriched on Snail gene but not on β-actin gene, n = 3. (C) Dual-luciferase assay showed that BAP1-enhanced Snail promoter activity by about fourfold compared with control empty vector, n = 3. *p < 0.05; **p < 0.01; ***p < 0.001.
