SETD1A and RAD18 mutually influence mRNA and protein expression.
A, Protein expression of SETD1A, RAD18, and control proteins following disruption of SETD1A and RAD18 using siRNA. B, Expression of trimethylated histone H3 lysine 4, ubiquitinated histone H2B, and β-tubulin following disruption of SETD1A and RAD18 using siRNA. C, mRNA expression for genes encoding SETD1A, RAD18, and controls following disruption of SETD1A and RAD18 expression.