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. 2019 Jun 12;116(26):12958–12963. doi: 10.1073/pnas.1903896116

Fig. 3.

Fig. 3.

Lapf deficiency impairs LPS-activated endocytosis of TLR4 and production of TNF-α, IL-6, and IFN-β. (A) ELISA of TNF-α, IL-6, and IFN-β in the supernatant of Lapf+/− and Lapf−/− macrophages stimulated with LPS (100 ng/mL) for the indicated times. (B) ELISA of TNF-α, IL-6, and IFN-β in serum of Lapf+/− and Lapf−/− mice challenged by LPS (10 mg/kg) for 3 h. (C) Percentage of surface TLR4 on Lapf+/− and Lapf−/− BMDMs (bone marrow-derived macrophages) upon LPS (100 ng/mL) stimulation. Data are presented as mean ± SD of three independent experiments. *P < 0.05.