Table 2. Summary of cognitive test results comparing pre and post-intervention for each group, derived from repeated measures GEE.
Test | Group | Pre-intervention | Post-intervention | Ptime | Pgroup | Pgroup time | |||
---|---|---|---|---|---|---|---|---|---|
Mean | Standard error | Mean | Standard error | ||||||
CAMCOG | |||||||||
Executive functioning | SHAM | 113.55 | 1487 | 116 | 1.271 | 0.709 | 0.001 | 0.047 | |
Active | 111.17 | 2130 | 115.31 | 2.334 | |||||
Constructional praxis | SHAM | 2.28 | 0.137 | 2.69 | 0.139 | 0.146 | 0.609 | 0.037 | |
Active | 2.43 | 0.132 | 2.36 | 0.145 | |||||
Total language | SHAM | 27.45 | 0.27 | 27.28 | 0.344 | 0.374 | 0.963 | 0.116 | |
Active | 27.03 | 0.401 | 27.66 | 0.332 | |||||
Motor response | SHAM | 3.86 | 0.064 | 3.86 | 0.064 | 0.315 | 0.632 | 0.315 | |
Active | 3.83 | 0.098 | 3.97 | 0.034 | |||||
Verbal answer | SHAM | 2.93 | 0.047 | 3 | 0.049 | 0.763 | 0.698 | 0.362 | |
Active | 2.97 | 0.059 | 2.93 | 0.047 | |||||
Reading | SHAM | 2 | 0 | 2.03 | 0.034 | 0.980 | 0.096 | 0.150 | |
Active | 1.97 | 0.034 | 1.93 | 0.047 | |||||
Settings | SHAM | 5.62 | 0.133 | 5.66 | 0.132 | 0.130 | 0.733 | 0.215 | |
Active | 5.41 | 0.192 | 5.76 | 0.093 | |||||
Picture naming | SHAM | 7.86 | 0.08 | 7.76 | 0.18 | 0.527 | 0.519 | 0.750 | |
Active | 7.9 | 0.057 | 7.86 | 0.064 | |||||
Verbal fluency | SHAM | 4.17 | 0.162 | 3.9 | 0.171 | 0.772 | 0.876 | 0.049 | |
Active | 3.97 | 0.192 | 4.17 | 0.201 | |||||
Memory | SHAM | 20.59 | 0.456 | 21.48 | 0.432 | 0.006 | 0.731 | 0.766 | |
Active | 20.24 | 0.666 | 21.34 | 0.655 | |||||
Memory recall | SHAM | 4 | 0.213 | 3.32 | 0.202 | 0.303 | 0.361 | 0.004 | |
Active | 3.28 | 0.228 | 3.58 | 0.186 | |||||
Memory recognition | SHAM | 5.21 | 0.165 | 5.41 | 0.134 | 0.409 | 0.394 | 0.560 | |
Active | 5.14 | 0.181 | 5.17 | 0.169 | |||||
Remote Memory | SHAM | 4.31 | 0.213 | 4.83 | 0.176 | 0.003 | 0.434 | 0.345 | |
Active | 4.62 | 0.198 | 4.9 | 0.209 | |||||
Recent memory | SHAM | 3.69 | 0.139 | 3.79 | 0.113 | 0.752 | 0.151 | 0.253 | |
Active | 3.62 | 0.124 | 3.45 | 0.151 | |||||
Fixing address | SHAM | 3.61 | 0.234 | 4.28 | 0.145 | <0.001 | 0.696 | 0.881 | |
Active | 3.72 | 0.219 | 4.34 | 0.164 | |||||
Heads up | SHAM | 6.17 | 0.234 | 6 | 0.218 | 0.918 | 0.621 | 0.321 | |
Active | 5.83 | 0.32 | 6.03 | 0.251 | |||||
Calculation | SHAM | 1.85 | 0.067 | 1.83 | 0.07 | 0.478 | 0.939 | 0.300 | |
Active | 1.79 | 0.075 | 1.9 | 0.077 | |||||
Praxis | SHAM | 10.79 | 0.185 | 11.14 | 0.193 | 0.125 | 0.157 | 0.626 | |
Active | 10.52 | 0.252 | 10.69 | 0.224 | |||||
Ideational praxis | SHAM | 3.76 | 0.093 | 3.76 | 0.079 | 0.810 | 0.584 | 0.810 | |
Active | 3.83 | 0.07 | 3.79 | 0.09 | |||||
Constructional praxis | SHAM | 2.28 | 0.137 | 2.69 | 0.139 | 0.146 | 0.609 | 0.037 | |
Active | 2.43 | 0.132 | 2.36 | 0.145 | |||||
Ideomotor praxis | SHAM | 4.76 | 0.079 | 4.69 | 0.11 | 0.694 | 0.089 | 0.269 | |
Active | 4.41 | 0.158 | 4.55 | 0.115 | |||||
Tactile perception | SHAM | 2 | 0 | 1.97 | 0.034 | 0.565 | 0.556 | 0.565 | |
Active | 1.97 | 0.034 | 1.97 | 0.034 | |||||
Visual sense | SHAM | 7.52 | 0.143 | 6.93 | 0.188 | <0.001 | 0.812 | 0.908 | |
Active | 7.59 | 0.15 | 6.97 | 0.21 | |||||
Abstract thinking | SHAM | 6.1 | 0.317 | 6.38 | 0.332 | 0.011 | 0.691 | 0.156 | |
Active | 5.63 | 0.301 | 6.59 | 0.303 | |||||
Time orientation | SHAM | 4.72 | 0.096 | 4.86 | 0.064 | 0.994 | 0.510 | 0.112 | |
Active | 4.79 | 0.075 | 4.66 | 0.132 | |||||
Spatial orientation | SHAM | 4.83 | 0.07 | 4.9 | 0.057 | 0.701 | 0.905 | 0.08 | |
Active | 4.9 | 0.057 | 4.93 | 0.047 | |||||
Total | SHAM | 113.55 | 1.487 | 116 | 1,271 | <0.001 | 0.536 | 0.295 | |
Active | 111.17 | 2.130 | 115.31 | 2,334 | |||||
Final | SHAM | 93.93 | 0.979 | 95.83 | 0.686 | 0.001 | 0.579 | 0.742 | |
Active | 92.83 | 1.447 | 95.14 | 1,602 | |||||
Trail Making Test | |||||||||
Version A – time | SHAM | 0.5697 | 0.06614 | 0.6462 | 0.08633 | 0.631 | 0.104 | 0.09 | |
Active | 0.8269 | 0.11021 | 0.7707 | 0.09325 | |||||
Version A – errors | SHAM | 1.13 | 0.117 | 1.12 | 0.122 | 0.780 | 0.623 | 0.765 | |
Active | 1.25 | 0.23 | 1.29 | 0.352 | |||||
Version B – time | SHAM | 24.872 | 0.29003 | 24,503 | 0.3288 | 0.874 | 0.962 | 0.929 | |
Active | 24.559 | 0.25994 | 24,455 | 0.25501 | |||||
Version B – errors | SHAM | 3 | 0.403 | 2.49 | 0.889 | 0.497 | 0.665 | 0.610 | |
Active | 3 | 1,156 | 1.84 | 0.563 | |||||
Word List Memory Task | |||||||||
WLMT-A1 | SHAM | 4.9 | 0.241 | 5.05 | 0.298 | 0.503 | 0.404 | 0.694 | |
Active | 4.69 | 0.244 | 4.86 | 0.307 | |||||
WLMT-A2 | SHAM | 6.24 | 0.222 | 6.52 | 0.279 | 0.061 | 0.724 | 0.310 | |
Active | 6.1 | 0.29 | 6.17 | 0.289 | |||||
WLMT-A3 | SHAM | 6.79 | 0.282 | 7.17 | 0.285 | 0.263 | 0.838 | 0.524 | |
Active | 6.86 | 0.242 | 6.97 | 0.295 | |||||
WLMT-recall | SHAM | 5.85 | 0.302 | 5.14 | 0.361 | 0.987 | 0.694 | 0.007 | |
Active | 4.97 | 0.351 | 5.66 | 0.451 | |||||
WLMT-recall test: intrusions | SHAM | 1.28 | 0.171 | 1.22 | 0.139 | 0.941 | 0.205 | 0.851 | |
Active | 1.57 | 0.396 | 1.6 | 0.357 | |||||
WLMT-recognition test | SHAM | 9.1 | 0.171 | 8.93 | 0.212 | 0.412 | 0.615 | 0.995 | |
Active | 8.97 | 0.21 | 8.79 | 0.343 | |||||
WLMT-recognition test – intrusions |
SHAM | 1.28 | 0.176 | 0.96 | 0.103 | 0.395 | 0.021 | 0.091 | |
Active | 1.65 | 0.284 | 1.81 | 0.363 | |||||
WLMT-total | SHAM | 17.93 | 0.589 | 18.59 | 0.697 | 0.373 | 0.593 | 0.789 | |
Active | 17.66 | 0.66 | 18 | 0.801 | |||||
Other tests | |||||||||
Semantic Verbal Fluency
test (Animal word version) |
SHAM | 17.31 | 0.867 | 16.86 | 0.903 | 0.81 | 0.874 | 0.268 | |
Active | 16.55 | 0.972 | 17.24 | 0.971 | |||||
Mini-Mental
State Examination test |
SHAM | 27.31 | 0.369 | 27.31 | 0.297 | 0.751 | 0.578 | 0.751 | |
Active | 26.93 | 0.5 | 27.14 | 0.48 | |||||
Boston Naming test | SHAM | 13.31 | 0.342 | 13.48 | 0.34 | 0.179 | 0.682 | 0.816 | |
Active | 13.1 | 0.31 | 13.34 | 0.273 | |||||
Hamilton Depression Rating Scale |
SHAM | 8.66 | 1.003 | 6.74 | 0.712 | 0.033 | 0.117 | 0.459 | |
Active | 10.31 | 1.394 | 9.13 | 1,259 | |||||
Clock Drawing Test | SHAM | 8.759 | 0.2881 | 9,241 | 0.1883 | 0.012 | 0.401 | 0.743 | |
Active | 8.345 | 0.4059 | 8,948 | 0.3957 | |||||
N-back | SHAM | 508 | 0 | 508 | 0 | 0.312 | 0.312 | 0.312 | |
Active | 500.48 | 7.386 | 508 | 0 | |||||
WAIS III - Code | SHAM | 39.07 | 3.225 | 38.93 | 3.276 | 0.7 | 0.613 | 0.77 | |
Active | 41.76 | 3.525 | 40.69 | 3.129 | |||||
WAIS III – Digit span DO | SHAM | 7.38 | 0.403 | 7.45 | 0.435 | 0.785 | 0.734 | 0.959 | |
Active | 7.52 | 0.337 | 7.62 | 0.385 | |||||
WAIS III – Digit span IO | SHAM | 4.17 | 0.201 | 3.79 | 0.277 | 0.184 | 0.45 | 0.595 | |
Active | 4.31 | 0.316 | 4.14 | 0.283 |