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. 2019 May 6;3(7):971–986. doi: 10.1002/hep4.1365

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© 2019 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Clinical, histopathologic, and molecular features of engrafted and not engrafted HCC biopsies. (A) Patient and biopsy characteristics of all transplanted biopsies, grouped by engraftment status. Calculations of significant differences (indicated in red) between engrafted versus not engrafted biopsies are shown underneath. Two‐sided Fisher’s exact tests for categorical data and two‐sided Mann‐Whitney U tests for ordinal data. (B) Unsupervised hierarchical clustering analysis. Biopsy (PDX) cohort (this study) combined with high‐grade (Edmondson III to IV) HCCs from TCGA cohort. Abbreviations: ALD, alcoholic liver disease; BCLC, Barcelona Clinic Liver Cancer; HBV, hepatitis B virus; HCV, hepatitis C virus; MELD, Model for End‐Stage Liver Disease; MVI, macrovascular invasion; NAFLD, nonalcoholic fatty liver disease.