Table 1.
Demographic and Clinical Parameters of Subjects With NAFLD With and Without OSA/Hypoxia
| Clinical Parameter | NAFLD With OSA/Hypoxia (n = 21) | NAFLD Without OSA/Hypoxia (n = 10) | P Value | Normal Values |
|---|---|---|---|---|
| Mean age | 13.0 ± 1.9 | 13.1 ± 2.3 | 0.8 | – |
| Male sex (%) | 67 | 50 | 0.4 | – |
| Hispanic ethnicity (%) | 86 | 100 | 0.2 | – |
| BMI z score | 2.3 ± 0.3 | 2.1 ± 0.3 | 0.3 | – |
| ALT (IU/L) | 131 ± 109 | 93 ± 63 | 0.3 | 10‐45 IU/L |
| AST (IU/L) | 79 ± 55 | 58 ± 27 | 0.2 | 15‐40 IU/L |
| Cholesterol (mg/dL) | 157 ± 38 | 121 ± 43 | 0.03 | ≤170 mg/dL |
| Triglycerides (mg/dL) | 148 ± 66 | 139 ± 59 | 0.7 | ≤150 mg/dL |
| HOMA‐IR | 10.0 ± 6.7 | 8.1 ± 9.0 | 0.5 | <2.60 |
| Adiponectin (μg/mL) | 6.6 ± 3.4 | 6.6 ± 2.9 | 1.0 | 3.5‐14 μg/mL |
| Leptin (ng/mL) | 30.6 ± 15.5 | 29.9 ± 11.1 | 0.5 | 2.0‐5.6 ng/mL |
| CRP (mg/dL) | 3.0 ± 3.5 | 1.8 ± 1.2 | 0.2 | <0.5 mg/dL |
| Uric acid (mg/dL) | 6.6 ± 1.5 | 5.9 ± 1.3 | 0.2 | 2.3‐5.4 mg/dL |
| Sleep parameters | ||||
| Apnea‐hypopnea index | 9.0 ± 8.2 | 0.9 ± 0.6 | 0.0002 | – |
| Oxygen nadir | 82.6 ± 6.4 | 87.8 ± 2.9 | 0.004 | – |
| % Time SaO2 <90% | 2.2 ± 3.8 | 0.1 ± 0.2 | 0.02 | – |
Abbreviations: CRP, C‐reactive protein; HOMA‐IR, homeostasis model assessment of insulin resistance.