Figure 2.

Hepatocyte ERα mediates the protective effects of TAM but not of E2 against HFD‐induced obesity, insulin resistance, and glucose intolerance. LERKO mice (n = 40) and their respective WT littermates (n = 40) were fed an HFD and treated with TAM, E2, or VEH for 12 weeks. (A) Body weight evolution and final body weight gain; (B) mean food intake; (C) body composition; (D) adipose tissue distribution; (E) intraperitoneal glucose tolerance tests and HOMA‐IR score. Data are expressed as mean ± SEM. P _i < 0.0001, interaction between treatments and genotypes; *indicates differences between VEH and treated (TAM or E2) mice within each genotype. *P < 0.05; **P < 0.01; ***P < 0.001. Abbreviation: HOMA‐IR, homeostasis model assessment of insulin resistance.