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. 2019 Apr 29;3(7):908–924. doi: 10.1002/hep4.1363

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© 2019 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Role of hepatocyte ERα to TAM or E2 regulation of hepatokines known to improve glucose and lipid homeostasis and/or to control food intake. LERKO mice (n = 18) and their respective WT littermates (n = 17) were fed an HFD and treated with TAM, E2, or VEH for 12 weeks. (A) Hepatic mRNA expression of hepatokines (Angptl4, Angptl6, Enho, Fgf21, Gdf15, Igf1, Igfbp1, and Igfbp2) in liver tissue samples. (B) Serum Gdf15 concentration in blood samples. (C) Gdf15 mRNA expression in white adipose tissues. Data are expressed as mean ± SEM. *indicates differences between VEH and treated (TAM or E2) mice within each genotype. *P < 0.05; **P < 0.01; ***P < 0.001. Abbreviation: Hprt, hypoxanthine phosphoribosyl transferase.