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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Biochem Biophys Res Commun. 2018 May 9;501(1):172–177. doi: 10.1016/j.bbrc.2018.04.207

Figure 2. Thrombin generation by LPS-stimulated PBMCs is potentiated by recombinant PDI protein and inhibited by the PDI inhibitor PACMA31.

Figure 2

Human PBMCs were treated with 100 ng/ml of LPS, followed by incubation with PBS or 100 μg/ml of recombinant wild-type PDI protein (PDI-wt) at 37°C for 4 hours (A). Thrombin generation was measured. Representative trace (left panel) and peak thrombin generation (right panel) are shown. **P < 0.01, t test. (B) Human PBMCs were treated with 100 ng/ml of LPS, followed by incubation with DMSO or PACMA31 at the indicated concentration. Representative trace of thrombin generation are shown.