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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Circ Genom Precis Med. 2019 May 6;12(6):e002390. doi: 10.1161/CIRCGEN.118.002390

Figure 4.

Figure 4.

Summary of expression changes for the key driver genes in LINCS. A, Expression changes of 7 AR-RGN key drivers induced by 15 antiretroviral therapy (ART) drugs profiled in LINCS. Four key drivers have validated relationships with cholesterol ester accumulation. Median Z-score of gene expression ranks are shown within each cell. B, Expression changes of 7 AR-RGN key drivers in response to ritonavir, nelfinavir, saquinavir, maraviroc, and raltegravir. Persistent induction of PQBP1 by ritonavir, and nelfinavir, across a range of cell-line contexts (color legend on the right; details at http://lincs.hms.harvard.edu/db/cells/) suggested that these compounds increase cholesterol accumulation, possibly by interacting with PQBP1. AR-RGN, atherosclerosis-related regulatory gene network.