Effects of antiretroviral (ART) drugs on gene expression in THP-1 foam
cells. A. Heat map of all differentially expressed genes comparing
treatments with DMSO versus ritonavir, nelfinavir, saquinavir and maraviroc,
respectively, in THP-1 foam cells incubated with acetylated LDL. B.
Volcano plots showing differentially expressed AR-RGN genes in THP-1 foam cells
following ART drug treatments. C. Permutation test showing the mean
connectivity (r, Pearson correlations, x-axis) of atherosclerosis-related
regulatory gene network (AR-RGN) genes (arrow) compared to the null distribution
of 1,000 random equally sized sets of genes in THP-1 foam cells following ART
drug treatments (color code indicates each ART drug).