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. 2019 Jun 24;9:512. doi: 10.3389/fonc.2019.00512

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Copyright © 2019 Couto, Segatto, Oliveira, Seixas, Schachtschneider and Collares.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Percentage of trials using different cell lines to form grafts in melanoma murine models for in vivo therapeutic screening. B16 stands for all B16 sublines. Skmel stands for all Skmel sublines. “Others” include UACC-62, A2058, Na11+, Melanoma xenograft (MEXF), K1735, K1735-M2, HT168-M1, MM96L, Me501, M-14, Me30966, D10, 205, MeWo, VM1, Mel-JD, MEXF 989, WM 266-4, human malignant melanoma (BRO), and M24 cell lines. (B) Percentage of trials using each of the B16 sublines in syngeneic tumor models of melanoma for screening in vivo. Obs.: B16 indicates articles that do not specify a B16 subline.