Table III.
Top 10 Gene Ontology terms showing statistically significant protein enrichment for plasma samples taken from patients having therapeutic hypothermia during cooling.
| Gene Ontology term | Number of observed genes | P-value | Benjamini's correction | Genes |
|---|---|---|---|---|
| Platelet degranulation | 11 | 1.6×10−17 | 3.5×10−15 | ALB, FGA, FGB, FGG, FN1, ITIH3, ORM1, PROS1, SERPINA1, SERPINA3, SERPINF2 |
| Acute-phase response | 9 | 7.8×10−17 | 1.2×10−14 | CRP, APCS, FN1, LBP, ORM1, SERPINA1, SERPINA3, SERPINF2, SAA1 |
| Fibrinolysis | 5 | 1.1×10−8 | 7.8×10−7 | FGA, FGB, FGG, PROS1, SERPINF2 |
| Negative regulation of endopeptidase activity | 6 | 3.3×10−7 | 1.8×10−5 | C4A, ITIH3, PROS1, SERPINA1, SERPINA3, SERPINF2 |
| Blood coagulation | 6 | 2.6×10−6 | 1.2×10−4 | FGA, FGB, FGG, HBB, PROS1, SERPINA1 |
| Blood coagulation, fibrin clot formation | 3 | 8.9×10−6 | 3.3×10−4 | FGA, FGB, FGG |
| Innate immune response | 7 | 1.1×10−5 | 3.3×10−4 | APCS, C4A, FGA, FGB, LBP, PGLYRP2, SAA1 |
| Platelet aggregation | 4 | 1.7×10−5 | 4.8×10−4 | FGA, FGB, FGG, HBB |
| Positive regulation of peptide hormone secretion | 3 | 4.2×10−5 | 1.0×10−3 | FGA, FGB, FGG |
| Plasminogen activation | 3 | 5.3×10−5 | 1.2×10−3 | FGA, FGB, FGG |
In the patients having therapeutic hypothermia, 22 proteins found in at least 5 found 9 samples with upregulation (>1.2-fold) or downregulation (<0.83-fold) during cooling were analyzed using DAVID software.