Table IV.
Top 10 Gene Ontology terms showing statistically significant protein enrichment for plasma samples taken from patients having therapeutic hypothermia after rewarming.
| Gene Ontology term | Number of observed genes | P-value | Benjamini's correction | Genes |
|---|---|---|---|---|
| Platelet degranulation | 10 | 3.7×10−14 | 1.3×10−11 | ALB, FGA, FGB, FGG, ITIH3, ORM1, PROS1, SERPINA1, SERPINA3, SERPINF2 |
| Acute-phase response | 8 | 1.8×10−13 | 3.2×10−11 | CRP, APCS, LBP, ORM1, SERPINA1, SERPINA3, SERPINF2, SAA1 |
| Negative regulation of endopeptidase activity | 8 | 6.7×10−10 | 8.2×10−8 | AGT, C4A, ITIH3, PROS1, SERPINA1, SERPINA3, SERPINF2, VTN |
| Fibrinolysis | 5 | 3.1×10−8 | 2.9×10−6 | FGA, FGB, FGG, PROS1, SERPINF2 |
| Innate immune response | 9 | 2.5×10−7 | 1.8×10−5 | APCS, APOL1, C1R, C1S, C4A, FGA, FHB, LBP, SAA1 |
| Lipoprotein metabolism process | 5 | 3.8×10−7 | 2.3×10−5 | ALB, APOC2, APOC3, APOE, APOL1 |
| Receptor-mediated endocytosis | 7 | 4.2×10−7 | 2.2×10−5 | ALB, APOE, APOL1, HBA1, HBB, SAA1, VTN |
| Protein polymerization | 4 | 1.0×10−6 | 4.8×10−5 | FGA, FGB, FGG, VTN |
| Blood coagulation | 6 | 9.9×10−6 | 4.0×10−4 | FGA, FGB, FGG, HBB, PROS1, SERPINA1 |
| Regulation of complement activation | 4 | 1.5×10−5 | 5.4×10−4 | C4A, C9, PROS1, VTN |
In the patients having therapeutic hypothermia, 28 proteins found in at least 5 found 9 samples with upregulation (>1.2-fold) or downregulation (<0.83-fold) after rewarming were analyzed using DAVID software.