FIG 3.

Marginal predicted means of daily (A) hot flash frequency and (B) score (frequency × intensity), (C) vaginal dryness or pain with intercourse, and (D) musculoskeletal pain or arthralgia during the double-blind treatment phase. Values at baseline (month 0) are observed mean. Daily frequency but not daily score of hot flashes in the tamoxifen arm increased significantly relative to the placebo arm (P for treatment effect = .02 and .16, respectively). There was no difference between arms on vaginal dryness or pain with intercourse and musculoskeletal pain or arthralgia (P for treatment effect = .40 and .41, respectively).