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Transcytosis and clearance of test antibodies with varying Fv charges.
| mAb ID | Clearance in cynomolgus monkeya (mL/d/kg) |
Transcytosis in MDCK-hFcRn cells (ng/mL) |
Fv chargea |
|---|---|---|---|
| Anti-LTα−4 | 5.78 | 3.8 | 4.1 |
| Anti-LTα | 14.9 | 6.0 | 8.1 |
| Anti-LTα+3 | 59.3 | 16.0 | 11.1 |
| Anti-HER2−4 | 6.63 | 3.2 | 2.1 |
| Anti-HER2 | 6.22 | 2.7 | 6.1 |
| Anti-HER2+5 | 51.1 | 20.5 | 11.1 |
aFrom Bumbaca Yadav, D. et al.4
Transcytosis data are shown as averages of reportable values from at least two independent experiments.
