Table 4.

CRC prediction model stratified by CRC stage, Cohort 1

	AUC	95% CI	P‐valueb	Sensitivity	Specificity	Youden's index
Early stage (N = 675, early stage CRC/healthy control = 217/458)
Model 1	0.670	0.637‐0.704	–	0.3733	0.9672	0.3404
Model 2	0.669	0.627‐0.710	0.9514	0.8341	0.4464	0.2805
Model 3	0.780	0.743‐0.817	<0.0001	0.5668	0.8337	0.4005
Model 1a	0.766	0.728‐0.804	–	0.4630	0.9169	0.3798
Model 2a	0.718	0.679‐0.757	0.0053	0.9259	0.4388	0.3647
Model 3a	0.797	0.762‐0.832	0.0005	0.8009	0.6051	0.4060
Advanced stage (N = 685, advanced stage CRC/healthy control = 227/458)
Model 1	0.692	0.658‐0.725	–	0.4159	0.9672	0.3831
Model 2	0.686	0.645‐0.726	0.8249	0.8142	0.5033	0.3174
Model 3	0.805	0.770‐0.840	<0.0001	0.5752	0.8621	0.4374
Model 1a	0.752	0.712‐0.792	–	0.4595	0.9284	0.3879
Model 2a	0.705	0.665‐0.746	0.0190	0.7568	0.5497	0.3064
Model 3a	0.794	0.757‐0.831	<0.0001	0.6802	0.7460	0.4261

Model 1 includes FOBT. Model 2 includes PlGF. Model 3 includes FOBT and PlGF.

^aMultivariate logistic regressions were adjusted for age, sex, and BMI.

^b P‐value of the Model compared with Model 1.