Table 2.
Analysis of the four SNPs that passed the screen of discovery stage
| SNP | Allelea | Gene | Discovery stage | Replication stage | Combined stage | |||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P b | HR (95% CI) | P b | HR (95% CI) | P b | |||
| rs13167294 | A>C | PIK3R1 | 1.31 (1.07‐1.61) | 0.0104 | 1.45 (1.10‐1.91) | 0.0076 | 1.32 (1.13‐1.56) | 0.0007 |
| rs7839119 | C>A | FAK | 0.76 (0.62‐0.95) | 0.0138 | 1.02 (0.76‐1.36) | 0.8905 | 0.83 (0.70‐0.99) | 0.0369 |
| rs4983387 | G>A | ZBTB42 c | 1.21 (1.02‐1.42) | 0.0252 | 1.13 (0.87‐1.46) | 0.3525 | 1.18 (1.03‐1.35) | 0.0192 |
| rs342105 | T>C | RHOB | 1.57 (1.01‐2.44) | 0.0471 | 0.94 (0.57‐1.55) | 0.8068 | 1.13 (0.82‐1.56) | 0.4703 |
Abbreviations: HR, hazard ratio; SNP, single nucleotide polymorphism.
a
Reference allele/effect allele.
b
Calculated using Cox regression in an additive genetic model adjusting for age, gender, smoking, drinking status and clinical stage.
c
This SNP locates in the exon of ZBTB42, and 6.1kb upstream of AKT1.