Table 3.
Association between rs13167294 and overall survival in pancreatic cancer patients
| Discovery stage | Replication stage | Combined stage | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. (%) | MST | HR (95% CI) | P a | No. (%) | MST | HR (95% CI) | P a | No. (%) | MST | HR (95% CI) | P a | |
| PIK3R1 rs13167294 | ||||||||||||
| AA | 229 (67.2) | 8.32 | 1.00 (Reference) | 125 (60.7) | 10.62 | 1.00 (Reference) | 354 (64.7) | 8.95 | 1.00 (Reference) | |||
| AC | 103 (30.2) | 6.27 | 1.34 (1.05‐1.72) | 0.0192 | 72 (35.0) | 7.60 | 1.44 (1.02‐2.04) | 0.0373 | 175 (32.0) | 6.69 | 1.36 (1.11‐1.65) | 0.0026 |
| CC | 9 (2.6) | 4.83 | 1.57 (0.80‐3.07) | 0.1913 | 9 (4.4) | 3.75 | 2.13 (1.02‐4.43) | 0.0434 | 18 (3.3) | 4.67 | 1.63 (1.00‐2.67) | 0.0512 |
| Additive model | 1.31 (1.07‐1.61) | 0.0104 | 1.45 (1.10‐1.91) | 0.0076 | 1.32 (1.13‐1.56) | 0.0007 | ||||||
| Dominant model | 1.36 (1.07‐1.73) | 0.0117 | 1.51 (1.08‐2.10) | 0.0151 | 1.38 (1.14‐1.67) | 0.0010 | ||||||
| Recessive model | 1.45 (0.74‐2.82) | 0.2812 | 1.88 (0.92‐3.87) | 0.0859 | 1.48 (0.91‐2.42) | 0.1119 | ||||||
Abbreviation: HR, hazard ratio; MST, median survival time.
a
Calculated using Cox regression adjusting for age, gender, smoking, drinking status and clinical stage.