Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
KMT2A is recruited by p65 and co‐promotes cathepsin Z (CTSZ) transcriptional activation. A, A ChIP assay was performed that p65 binding CTSZ promoter region. B, Luciferase assay results showed that KMT2A transactivation of the CTSZ transcription. C, CTSZ expression in HCT116 cells when p65 overexpression and knockdown. D, Knockdown of p65 affected KMT2A binding on CTSZ promoter. E, Alternation of CTSZ levels regulated Snail and MMP2 expression in both HCT116 and DLD1 cell lines
