Table 1.

Bivariate association of selected prognostic factors and overall survival

Prognostic factor		RR	95% CI	P
Age		1	0.996‐1.003	0.804
Male gender		0.93	0.835‐1.035	0.184
Location	Right*	1	—	0.106
	Transverse	0.857	0.608‐1.207	0.377
	Left	1.04	0.811‐1.334	0.756
	Sigmoid	1.056	0.885‐1.259	0.548
	Rectum	1.163	1.013‐1.335	0.032
Basal hemoglobin		0.943	0.924‐0.962	<0.0001
Basal serum albumin		0.726	0.673‐0.784	<0.0001
Basal lymphocyte count		1	1‐1	<0.0001
PNI		0.968	0.962‐0.974	<0.0001
Carcinoembryonic antigen		1	1‐1	0.942
Neutrophil/lymphocyte count		1.038	1.029‐1.047	<0.0001
Platelet/lymphocyte count		1.709	1.493‐1.956	<0.0001
Neutrophil/platelet count		1.003	1.001‐1.005	0.003
Differentiation degree	Well*	1	—	<0.0001
	Moderate	1.344	1.14‐1.586	<0.0001
	Poor	1.882	1.53	<0.0001
	Undifferentiated	1.27	0.97‐1.664	0.082
TNM classification	I*	—	—	<0.0001
	IIa	3.064	1.823‐5.149	<0.0001
	IIb	3.386	1.733‐6.615	<0.0001
	IIc	8.604	4.958‐14.932	<0.0001
	IIIa	1.39	0.661‐2.922	0.385
	IIIb	2.575	1.477‐4.49	0.001
	IIIc	7.198	4.286‐12.088	<0.0001
	IVa	9.35	5.568‐15.701	<0.0001
	IVb	11.704	6.926‐19.779	<0.0001
R classification	R0*	1	—	<0.0001
	R1	1.454	1.027‐2.059	0.035
	R2	2.945	2.505‐3.462	<0.0001
	No surgical resection	5.792	5.104‐6.572	<0.0001
Surgical morbidity	grade 0*	1	—	0.655
	grade 1‐2	0.907	0.57‐1.445	0.682
	grade 3‐4	0.89	0.676‐1.171	0.405
Adjuvant chemotherapy		0.38	0.333‐0.434	<0.0001

CI, confidence interval; p, probability value; PNI, prognostic nutritional index; R, residual disease classification; surgical morbidity after Clavien‐Dindo classification; RR: risk ratio.

^*Reference category.