Table 2.
Final model of the multivariate analysis of prognostic factors associated with overall survival (P < 0.0001)
| Prognostic factor | β (SE) | Exp β | 95% CI | P | |
|---|---|---|---|---|---|
| Location | Right* | — | 1 | — | 0.08 |
| Transverse | −0.309 (0.177) | 0.734 | 0.519‐1.037 | 0.08 | |
| Left | 0.077 (0.129) | 1.08 | 0.838‐1.391 | 0.552 | |
| Sigmoid | 0.092 (0.093) | 1.096 | 0.914‐1.315 | 0.321 | |
| Rectum | −0.074 (0.075) | 0.929 | 0.801‐1.077 | 0.33 | |
| Basal hemoglobin | (unit) | −0.027 (0.013) | 0.973 | 0.949‐0.998 | 0.033 |
| Lymphocyte | <1300 cells/mm3 * | — | 1 | — | <0.0001 |
| 1300‐1700 cells/mm3 | 0.038 (0.1) | 1.039 | 0.854‐1.265 | 0.701 | |
| 1701‐1980 cells/mm3 | 0.331 (0.108) | 1.393 | 1.127‐1.721 | 0.002 | |
| 1981‐2400 cells/mm3 | 0.089 (0.114) | 1.093 | 0.875‐1.367 | 0.433 | |
| >2400 cells/mm3 | −0.223 (0.138) | 0.8 | 0.611‐1.049 | 0.106 | |
| Neutrophil/lymphocyte ratio | (unit) | 0.031 (0.007) | 1.031 | 1.018‐1.044 | <0.0001 |
| Neutrophil/lymphocyte ratio | <1.71* | — | 1 | — | 0.047 |
| 1.17‐2.34 | −0.022 (0.103) | 0.978 | 0.799‐1.196 | 0.828 | |
| 2.34‐2.79 | 0.236 (0.105) | 1.266 | 1.031‐1.553 | 0.024 | |
| 2.8‐4 | 0.054 (0.111) | 1.055 | 0.849‐1.312 | 0.628 | |
| >4 | 0.122 (0.133) | 1.13 | 0.871‐1.465 | 0.358 | |
| Platelet/lymphocyte ratio | <0.13* | — | 1 | — | 0.1 |
| 0.13‐0.17 | −0.204 (0.096) | 0.816 | 0.675‐0.985 | 0.034 | |
| 0.17‐0.22 | −0.105 (0.102) | 0.9 | 0.737‐1.101 | 0.305 | |
| 0.22‐0.31 | −0.262 (0.111) | 0.769 | 0.619‐0.957 | 0.019 | |
| >0.31 | −0.248 (0.134) | 0.781 | 0.6‐1.015 | 0.064 | |
| PNI | <34* | — | 1 | — | <0.001 |
| 34.1‐43.4 | −0.311 (0.093) | 0.732 | 0.611‐0.878 | 0.001 | |
| 43.5‐47 | −0.422 (0.109) | 0.656 | 0.529‐0.813 | <0.0001 | |
| >47 | −0.436 (0.11) | 0.646 | 0.521‐0.802 | <0.0001 | |
| Differentiation degree | Well* | — | 1 | — | 0.002 |
| Moderate | 0.242 (0.085) | 1.274 | 1.078‐1.506 | 0.005 | |
| Poor/undifferentiated | 0.352 (0.099) | 1.421 | 1.169‐1.727 | <0.0001 | |
| TNM classification | I* | — | 1 | — | <0.0001 |
| IIa | 0.98 (0.266) | 2.665 | 1.584‐4.484 | <0.0001 | |
| IIb | 0.898 (0.344) | 2.455 | 1.251‐4.817 | 0.009 | |
| IIc | 1.561 (0.285) | 4.765 | 2.727‐8.325 | <0.0001 | |
| IIIa | 0.2 (0.38) | 1.222 | 0.58‐2.572 | 0.598 | |
| IIIb | 0.856 (0.285) | 2.354 | 1.348‐4.112 | 0.003 | |
| IIIc | 1.551 (0.267) | 4.715 | 2.793‐7.959 | <0.0001 | |
| IVa | 1.228 (0.272) | 3.416 | 2.004‐5.82 | <0.0001 | |
| IVb | 1.369 (0.275) | 3.932 | 2.292‐6.745 | <0.0001 | |
| R classification | R0* | — | 1 | — | <0.0001 |
| R1 | 0.281 (0.18) | 1.324 | 0.931‐1.883 | 0.118 | |
| R2 | 0.895 (0.098) | 2.446 | 2.018‐2.965 | <0.0001 | |
| No surgical resection | 1.56 (0.082) | 4.759 | 4.053‐5.589 | <0.0001 | |
| Postoperative complication | (any) | 0.25 (0.076) | 1.284 | 1.106‐1.491 | 0.001 |
β, regression coefficient; CI, confidence interval of the beta exponent; exp β, beta exponent (corresponds to risk ratio); p, probability value; PNI, prognostic nutritional index; SE, standard error.
*
Reference category.