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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Neuroimage. 2018 Dec 15;188:572–583. doi: 10.1016/j.neuroimage.2018.12.009

Table 2.

Baseline associations between vascular burden and APOE ε4 status with DTI parameters Results are from separate models for each predictor variable, controlling for baseline age, sex, race, and scanner.

FA
 MD
Vascular Burden
 APOE ε4
 Vascular Burden
 APOE ε4
Beta 95% C.I. Effect Size¥ Beta 95% C.I. Effect Size Beta 95% C.I. Effect Size¥ Beta 95% C.I. Effect Size
Superior Longitudinal.Fasciculus −0.0025* −0.0048, −0.00022 −0.087 −0.0023 −0.0075, 0.0028 −0.08 4.10e-06† 1.5e-06, 6.8e-06 0.11 5.50e-06 −4.5e-07, 1.1e-05 −0.06
Sup. Franto-Occ. Fasc. −0.0017 −0.0053, 0.0019 −0.04 −0.0016 −0.0096, 0.0063 −0.04 8.30e-06* 1.7e-06, 1.5e-05 0.08 5.30e-06 −9.7e-06, 2e-0S −0.08
Int Pronto-Occ. Fasc. −0.0017 −0.0038, 0.00035 −0.06 −0.0028 −0.0074, 0.0018 −0.10 −1.70e-06 −5.1e-06,1.8e-06 −0.03 7.20e-06 −4.3e-07, 1.5e-05 0.02
Sagittal stratum −0.004† −0.0065, −0.0015 −0.13 −0.0035 −0.0091, 0.0021 −0.11 2.60606 −4e-07, 5.6e-06 0.06 7.70e-06* 1.1e-06, 1Ae-05 −0.02
Cingulum (gyrus) −0.00065 −0.0032, 0.0019 −0.02 −0.0026 −0.0081, 0.003 −0.08 3.30e-06* 7.8e-07, 5.9e-06 0.09 2.50e-06 −3.2e-06, 8.2e-06 −0.08
Cingulum (hipp.) 0.0021 −0.0012, 0.0054 0.05 −0.00022 −0.0076, 0.0071 0.00 −8.10e-07 −4.9e-06, 3.3e-06 −0.01 −4.90e-06 −1.4e-05, 4.2e-06 0.03
Fornix (crus) −0.0025* −0.0044, −0.00062 −0.09 0.00042 −0.0038, 0.0046 0.02 110606 −3.2e-06, 5.5e-06 0.02 2.70e-06 −6.9e-06, 1.2e-05 0.06
Fornix (body) −00.0052020 −0.0082, −0.0019 −0.09 −0.0028 −0.0098, 0.0043 −0.05 150e-05* 2.8.07, 3e-05 0.06 −1.80e-OS −5.1e-05, 1.6e-OS 0.16
CC. Genu −0.0062† −0.01, −0.0023 −0.11 0.0037 −0.005, 0.012 0.06 1.00e-05 −2e-07, 21e-05 0.06 −5,00e-06 −2.9e-05, 1.9e-05 −0.18
CC. Body −0.0061† −0.0091, −0.0031 −0.15 0.0027 −0.004, 0.0095 0.06 1.00e-05† 4.5e-06, 1.6.05 0.11 1.50e-06 −1.2e-0S, 1.5e-05 −0.07
CC. Splenium −0.0026* −0.005, −0.00019 −0.08 −7.30e-05 −0.0055, 0.0053 0.00 3.40e-06 −2.1e-06, 8.9e-06 0.04 1.70e-06 −le-OS, 1.4e-05 −0.15
Ant. Corona Radian −0.0038f −0.0062, −0.0014 −0.10 −0.0018 −0.0072, 0.0036 −0.05 4.40e-06* 7.1e-07, 8e-06 0.07 5.00e-06 −3.2e-06, 1.3.05 −0.12
Sup. Canna Radiant −0.0018 −0.0044, 0.00067 −0.06 −0.0016 −0.0071, 0.0039 −0.05 6.20e-06† 2.9e-06, 9.4e-06 0.13 2.90e-06 −4.4e-06, 1e-05 −0.01
Post. Corona Radials −0.00099 −0.0046, 0.0026 −0.02 −0.0027 −0.011, 0.0053 −0.06 3.60e-06 −4.5e-07, 7.6e-06 0.07 5.20e-06 −3.9e-06, 1.4e-05 0.00
Ant. Limb Int. Capsule −0.0036* −0.0068, −0.00038 −0.08 0.002 −0.0051, 0.0092 0.05 4.80e-06 −1.8e-07, 9.9e-06 0.06 8.30e-07 −1e-05, 1.2e-05 −0.04
Post. Limb Inc. Capsule −0.00095 −0.0034, 0.0015 −0.03 −0.00081 −0.0063, 0.0046 −0.03 3.00e-06* 5.5e-07, 5.4e-06 0.08 4.40e-06 −1e-06, 9.8e-06 −0.08
*

significant at p < 0.05.

†

significant at p < 0.01.

¥

Effect sizes represents the effect for one-unit change in vascular burden score.