Skip to main content
. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Neuroimage. 2018 Dec 15;188:572–583. doi: 10.1016/j.neuroimage.2018.12.009

Table 5.

The associations between vascular burden, APOE ε4 carrier status, and their interaction term, on the rates of change in DTI parameters. Results are from the same model controlling for baseline age, sex, race, and scanner.

FA
Vascular Burden*Time
 APOE status*Time
 Vascular Burden*APOE status*Time
Beta 95% C.I. Effect
Size¥ 		Beta 95% C.I. Effect
Size		 Beta 95% C.I. Effect
Size
Sup. Long. Fasc. 8.20e-06 −0.00051, 0.00053 0.00 0.00012 −0.0021, 0.0024 0.02 −0.00049 −0.0016, 0.00065 −0.07
Sup. Fronto-Occ. Fasc. −3.00e-04 −0.0012, 0.00059 −0.03 −7.00e-04 −0.0045, 0.0031 −0.06 5.70E-05 −0.0019, 0.002 0.01
Inf. Fronto-Occ. Fasc. 3.00e-05 −0.00061, 0.00055 0.00 0.00019 −0.0026, 0.0023 −0.02 0.00021 −0.001, 0.0015 0.03
Sagittal stratum 0.00018 −0.00056, 0.00092 0.02 0.001 −0.0022, 0.0043 0.10 −0.00068 −0.0023, 0.00094 −0.06
Cingulum (gyrus) −9.90e-06 −0.00058, 0.00056 0.00 −0.00033 −0.0028, 0.0022 −0.05 −8.70e-05 −0.0014, 0.0012 −0.01
Cingulum (hipp.) −0.0015* −0.0028, −0.00019 −0.07 0.0041 −0.0015, 0.0098 0.20 0.0016 −0.0044, 0.0013 −0.08
Fornix (crus) −0.00083* −0.0015, −0.00018 −0.09 −0.00083 −0.0036, 0.002 −0.09 0.00088 −0.00053, 0.0023 0.10
Fornix (body) −0.00035 −0.0011, 0.00039 −0.04 −0.00081 −0.004, 0.0024 −0.09 0.0012 −0.00045, 0.0027 0.13
CC. Genu 0.00012 −0.00097, 0.0012 0.01 −0.0048* −0.0095, 8.4e-05 −0.33 0.0011 −0.0013, 0.0035 0.08
CC. Body −0.00061 −0.0015, 0.00028 −0.05 −0.0017 −0.0056, 0.0021 −0.14 0.00018 −0.0018, 0.0021 0.02
CC. Splenium −0.00053 −0.0012, 0.00015 −0.05 −0.0014 −0.0043, 0.0015 −0.14 −0.00015 −0.0016, 0.0013 −0.01
Ant. Corona Radiata 5.40e-05 −0.00044, 0.00055 0.01 −0.0013 −0.0034, 0.00087 −0.22 2.00e-04 −0.00089, 0.0013 0.03
Sup. Corona Radiata 0.00035 −4.4e-05, 0.00075 0.07 0.0013 −0.00037, 0.003 0.28 −0.00087* −0.0017, 1.1e-05 −0.19
Post. Corona Radiata 0.00018 −0.00042, 0.00079 0.03 0.0016 −0.00098, 0.0042 0.23 −0.001 −0.0023, 0.00031 −0.14
Ant. Limb Int. Capsule 0.00038 −0.00057, 0.0013 0.03 0.0022 −0.0019, 0.0063 0.17 −0.0016 −0.0036, 0.00048 −0.12
Post. Limb Int. Capsule −7.20e-05 −0.00065, 0.00051 −0.01 −0.00037 −0.0028, 0.0021 −0.05 −0.00019 −0.0014, 0.0011 −0.02
MD
Vascular Burden*Time
 APOE status*Time
 Vascular Burden*APOE status*Time
Beta 95% C.I. Effect
Size¥ 		Beta 95% C.I. Effect
Size		 Beta 95% C.I. Effect
Size
Sup. Long. Fasc. 2.10e-07 −3.1e-07, 7.2e-07 0.03 1.70e-06 −5.7e-07, 4.1e-06 0.24 −7.00e-07 −1.9e-06, 4.9e-07 −0.10
Sup. Fronto-Occ. Fasc. −6.60e-07 −2.3e-06, 1e-06 −0.03 −4.90e-06 −1.2e-05, 2.5e-06 −0.25 2.40e-06 −1.4e-06, 6.3e-06 0.12
Inf. Fronto-Occ. Fasc. −4.90e-08 −1.1e-06, 9.8e-07 0.00 6.10e-07 −3.7e-06, 4.9e-06 0.04 −9.90e-07 −3.2e-06, 1.2e-06 −0.07
Sagittal stratum −2.30e-07 −1.3e-06, 8.5e-07 −0.02 −7.60e-07 −5.5e-06, 4e-06 0.05 1.80e-07 −2.2e-06, 2.6e-06 0.01
Cingulum (gyrus) −2.10e-07 −8.3e-07, 4.1e-07 −0.03 6.80e-07 −2e-06, 3.4e-06 −0.09 −4.70e-07 −1.8e-06, 8.9e-07 −0.06
Cingulum (hipp.) 1.90e-06* 3.3e-07, 3.5e-06 0.08 3.20e-06 −3.6e-06, 1e-05 0.14 −2.60e-06 −6e-06, 8.3e-07 −0.12
Fornix (crus) 1.00e-06 −5.5e-07, 2.6e-06 0.04 2.00e-06 −4.8e-06, 8.7e-06 0.09 −2.40e-06 −5.8e-06, 1e-06 −0.11
Fornix (body) 2.70e-07 −3.2e-06, 3.7e-06 0.01 1.50e-05* 4.1e-07, 3e-05 0.35 1.00e-05† −1.8e-05, −2.7e-06 −0.24
CC. Genu 3.40e-07 −2.9e-06, 3.6e-06 0.01 9.40e-06 −4.5e-06, 2.3e-05 0.21 4.80e-06 −1.2e-05, 2.3e-06 −0.11
CC. Body 2.20e-06* 7.4e-08, 4.4e-06 0.07 4.30e-06 −4.9e-06, 1.4e-05 0.13 1.90e-06 −6.5e-06, 2.8e-06 −0.06
CC. Splenium 3.00e-06y 1.3e-06, 4.7e-06 0.12 6.40e-06 −1e-06, 1.4e-05 0.25 2.90e-06 −6.6e-06, 8.2e-07 −0.11
Ant. Corona Radiata 1.00e-07 −6.6e-07, 8.6e-07 0.01 1.50e-06 −1.8e-06, 4.9e-06 0.13 4.10e-07 −2.1e-06, 1.3e-06 −0.04
Sup. Corona Radiata −6.40e-09 −6.6e-07, 6.4e-07 0.00 5.50e-07 −2.3e-06, 3.4e-06 0.07 1.50e-07 −1.7e-06, 1.4e-06 −0.02
Post. Corona Radiata 4.40e-07 −3.2e-07, 1.2e-06 0.04 −1.00e-07 −3.4e-06, 3.2e-06 −0.01 1.10e-07 −1.6e-06, 1.8e-06 0.01
Ant. Limb Int. Capsule −2.10e-07 −1.7e-06, 1.3e-06 −0.01 −1.00e-06 −7.5e-06, 5.5e-06 −0.05 1.10e-06 −2.1e-06, 4.4e-06 0.05
Post. Limb Int. Capsule −2.90e-07 −9.5e-07, 3.8e-07 −0.03 4.10e-07 −2.5e-06, 3.3e-06 0.04 3.90e-07 −1.9e-06, 1.1e-06 −0.04
*

significant at p < 0.05.

†

significant at p < 0.01.

¥

Effect sizes represents the effect for one-unit change in vascular burden score.