. Author manuscript; available in PMC: 2020 May 1.

Published in final edited form as: Alcohol Clin Exp Res. 2019 Apr 8;43(5):791–802. doi: 10.1111/acer.14000

Table 1.

Putative mechanisms of action for positive allosteric modulators (PAMs) targeting specific GABA_A receptor subunits

Compound	Mechanism of action
Triazolam¹	Nonselective benzodiazepine PAM
MRK-696²	Nonselective benzodiazepine partial PAM
QH-ii-066³	α5GABA_A receptor-preferring PAM
Zolpidem¹	ɑ1GABA_A receptor-preferring PAM
L-838,417²	Functionally selective partial PAM at α2/3/5GABA_A receptors that lacks efficacy at α1GABA_A receptors (α1-sparing compound)
YT-III-31^4,5	Functionally selective PAM at α3GABA_A receptors
YT-III-271⁴	Functionally selective PAM at α3GABA_A receptors
HZ-166⁶	Functionally selective PAM at α2GABA_A and α3GABA_A receptors
XHe-II-053⁶	Functionally selective PAM at α2GABA_A and α3GABA_A receptors

Huang et al., 2003

⁴

⁵

⁶

α1/2/3/5GABA_A receptors = GABA_A receptors containing α1, α2, α3, and α5 subunits, respectively.