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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Neurosci Biobehav Rev. 2018 Nov 22;99:160–197. doi: 10.1016/j.neubiorev.2018.11.010

Table 3.

Neuropsychiatric Paradigms and Assessments Utilized in Human and Non-Human Animal Trials.

Human Non-Human
Paradigms/Assessments Associated References Paradigms/Assessments Associated References
Stress/Well-being 1. Socially Evaluated Cold Pressor Test – (SECPT)
2. Perceived Stress Scale – (PSS)
3. Hopkins Symptom Checklist-Revised – (HSCL-90) Psychological Distress
4. Depression Anxiety Stress Scale – (DASS)
5. Paced Auditory Serial Addition Test – (PASAT)
6. European Quality of Life – (EQ-5D-5L)
1. (Kelly et al., 2017)
2. (Chung et al., 2014; Kelly et al., 2017; Messaoudi et al., 2011a; Messaoudi et al., 2011b; Ostlund-Lagerstrom et al., 2016; Sanchez et al., 2017)
3. (Messaoudi et al., 2011a; Messaoudi et al., 2011b)
4. (Akkasheh et al., 2016; Mohammadi et al., 2016; Romijn et al., 2017)
5. (Moller et al., 2017)
6. (Ostlund-Lagerstrom et al., 2016)
1. Maternal Separation – (MS) or Early Life Stress
2. Restraint Stress – (RS)
3. Water Avoidance Stress – (WAS)
4. Unpredictable
5. Social Defeat
6. Stress-Induced Hypothermia
7. Stress
1. (Callaghan et al., 2016; Cowan et al., 2016; Desbonnet et al., 2010; Liu et al., 2016b; McVey Neufeld et al., 2017; Vanhaecke et al., 2017)
2. (Liang et al., 2015; McVey Neufeld et al., 2017)
3. (Gareau et al., 2011; Smith et al., 2014; Vanhaecke et al., 2017)
4. (Davis et al., 2016b; Dhaliwal et al., 2018; Parois et al., 2017)
5. (Bharwani et al., 2017)
6. (Bravo et al., 2011; Savignac et al., 2014)
7. (Davis et al., 2016a)
Anxiety 1. State Trait Anxiety Inventory – (STAI)
2. Beck Anxiety Inventory – (BAI)
3. Hamilton Anxiety Scale – (HAM-A)
4. Patient Health Questionnaire-9 – (PHQ-9)
5. Hospital Anxiety and Depression Scale – (HADS)
1. (Kato-Kataoka et al., 2016; Kelly et al., 2017; Reale et al., 2012; Sanchez et al., 2017; Slykerman et al., 2017; Takada et al., 2016)
2. (Akkasheh et al., 2016; Kelly et al., 2017; Steenbergen et al., 2015)
3. (Yang et al., 2016a)
4. (Lee et al., 2014)
5. (Lyra et al., 2016; Messaoudi et al., 2011a; Messaoudi et al., 2011b; Ostlund-Lagerstrom et al., 2016)
1. Elevated Plus Maze – (EPM)
2. Step Down Test – (SDT)
3. Light/Dark Box
4. Burying
5. Open Field Test – (OFT)
6. Locomotor activity
7. Thigmotaxis
8. Novel Tank Diving
9. Mirror Chamber Test
1. (Beilharz et al., 2017; Bravo et al., 2011; Cowan et al., 2016; Dhaliwal et al., 2018; Liang et al., 2015; Liu et al., 2016a; Liu et al., 2016b; Luo et al., 2014; Savignac et al., 2014; Wang et al., 2015)
2. (Arseneault-Breard et al., 2012; Bercik et al., 2011; Bercik et al., 2010)
3. (Bercik et al., 2010; Bharwani et al., 2017; Emge et al., 2016; Smith et al., 2014)
4. (Hsiao et al., 2013; Kantak et al., 2014; Messaoudi et al., 2011a; Savignac et al., 2014)
5. (Abildgaard et al., 2017a; Abildgaard et al., 2017b; Bharwani et al., 2017; Bravo et al., 2011; Buffington et al., 2016; Dhaliwal et al., 2018; Divyashri et al., 2015; Hsiao et al., 2013; Kantak et al., 2014; Liang et al., 2015; Liu et al., 2016b; McKernan et al., 2010; McVey Neufeld et al., 2017; Parois et al., 2017; Savignac et al., 2014; Tillmann et al., 2018; Vanhaecke et al., 2017)
6. (Davis et al., 2016a; Liu et al., 2016a; Liu et al., 2016b; Savignac et al., 2015; Wang et al., 2015)
7. (Davis et al., 2016a)
8. (Davis et al., 2016b; Schneider et al., 2016)
9. (Dhaliwal et al., 2018)
Depression 1. Beck Depression Inventory – (BDI)
2. Leiden Index of Depression Severity – (LEIDS)
3. Quick Inventory of Depressive Symptomatology – (QIDS)
4. Montgomery-Asberg Depression Rating Scale – (MADRS)
5. Hamilton Depression Scale – (HAM-D)
6. Edinburgh Postnatal Depression Scale – (EPDS)
7. Profile of Mood States – (POMS)
8. Hospital Anxiety and Depression Scale – (HADS)
9. General Health Questionnaire – (GHQ)
10. Patient Health Questionnaire-9 – (PHQ-9)
11. Inconsolable crying and fussiness
12. Positive and Negative Syndrome Scale – (PANSS)
13. Geriatric Depression Scale – (GDS)
1. (Akkasheh et al., 2016; Kelly et al., 2017; Kouchaki et al., 2016; Rao et al., 2009; Sanchez et al., 2017; Steenbergen et al., 2015)
2. (Steenbergen et al., 2015)
3. (Romijn et al., 2017)
4. (Romijn et al., 2017)
5. (Dapoigny et al., 2012)
6. (Slykerman et al., 2017)
7. (Benton et al., 2007; Michalickova et al., 2016)
8. (Lyra et al., 2016; Messaoudi et al., 2011a; Messaoudi et al., 2011b; Ostlund-Lagerstrom et al., 2016)
9. (Kouchaki et al., 2016; Mohammadi et al., 2016; Nishihira et al., 2014)
10. (Lee et al., 2014)
11. (Cekola et al., 2015; Indrio et al., 2014; Rinne et al., 2006; Sung et al., 2014; Weizman and Al sheikh, 2006)
12. (Dickerson et al., 2014)
13. (Chung et al., 2014)
1. Tail Suspension Test – (TST)
2. Forced Swim Test – (FST)
3. Immobility
4. Aggression
5. Gross Behavior
1. (Dhaliwal et al., 2018; Guida et al., 2017; Liang et al., 2017; Savignac et al., 2014)
2. (Abildgaard et al., 2017a; Abildgaard et al., 2017b; Arseneault-Breard et al., 2012; Bravo et al., 2011; Desbonnet et al., 2008; Desbonnet et al., 2010; Dhaliwal et al., 2018; Gilbert et al., 2013; Guida et al., 2017; Liang et al., 2017; Liu et al., 2016b; Savignac et al., 2014; Tillmann et al., 2018)
3. (D'Mello et al., 2015)
4. (Kantak et al., 2014)
5. (Nimgampalle and Kuna, 2017)
Cognitive Ability 1. Bayley Scale of Infant Development Motor and Psychomotor Indices – (BSID-IIMDI and PDI)
2. Mini Mental Status Examination – (MMSE)
3. Delta Power
4. Cognitive Restraint
5. Paced Auditory Serial Addition Test – (PASAT)
6. Wechsler MemoryScale - logical memory test
7. Rapid Visual Information Processing – (RVIP)
8. Digit Symbol
9. Trial Making Test (TMT) – Part A & B
10. Verbal fluency
11. Episodic memory
12. Paired Associative Learning – (PAL)
13. Stroop Emotion
14. Block Design
15. Attention Switching Task – (AST)
16. Storytelling
17. Fearful stimuli
1. (Akar et al., 2017)
2. (Akbari et al., 2016)
3. (Takada et al., 2017)
4. (Sanchez et al., 2017)
5. (Moller et al., 2017)
6. (Benton et al., 2007)
7. (Chung et al., 2014; Kelly et al., 2017)
8. (Bajaj et al., 2014; Malaguarnera et al., 2010)
9. (Malaguarnera et al., 2010)
10. (Benton et al., 2007)
11. (Benton et al., 2007)
12. (Kelly et al., 2017) Kelly et al., 2017)
13. (Kelly et al., 2017)
14. (Bajaj et al., 2014; Malaguarnera et al., 2010)
15. (Kelly et al., 2017)
16. (Chung et al., 2014)
17. (De Lorenzo et al., 2017; Tillisch et al., 2013)
1. Morris water maze – (MWM)
2. Cued and Contextual Fear Conditioning
3. Passive Avoidance Test – (PAT)
4. Novel Object Recognition – (NOR)
5. Object Placement Test – (OPT)
6. Prepulse Inhibition – (PPI)
7. Barnes maze
8. Y-maze
9. T-maze
10. Long-Term Potentiation (LTP)
11. Excitatory Post-Synaptic Potentials (EPSPs)
12. Memory
1. (Davari et al., 2013; Dhaliwal et al., 2018; Goudarzvand et al., 2016; Liang et al., 2017; Luo et al., 2014; McVey Neufeld et al., 2017; Musa et al., 2017; Nimgampalle and Kuna, 2017; Partty et al., 2015; Sun et al., 2016; Tian et al., 2017; Woo et al., 2014)
2. (Bravo et al., 2011; Callaghan et al., 2016; Cowan et al., 2016; Savignac et al., 2015)
3. (Gilbert et al., 2013; Lee et al., 2018; Woo et al., 2014)
4. (Beilharz et al., 2017; Emge et al., 2016; Lee et al., 2018; Liang et al., 2015; Mohle et al., 2016; Savignac et al., 2015; Smith et al., 2014; Tillmann et al., 2018)
5. (Liang et al., 2015)
6. (Hsiao et al., 2013)
7. (Abildgaard et al., 2017b; Savignac et al., 2015)
8. (Jeong et al., 2015; Jeong et al., 2016; Lee et al, 2018; Tillmann et al., 2018; Woo et al., 2014; Xiao et al., 2014)
9. (Gareau et al., 2011)
10. (Buffington et al., 2016; Chunchai et al., 2018; Davari et al., 2013; Distrutti et al., 2014)
11. (Chunchai et al., 2018; Davari et al., 2013)
12. (Parois et al., 2017)
Social Behavior and Functioning 1. Functional Assessment of Cancer Therapy: Social Well-being – (FACT-SWB)
2. Pediatric Quality of Life – (QOL) Social
3. IBS Quality of Life (QOL) Social Function
4. Sickness Impact Profile Social – (SIP-social)
5. Short Form-36 (SF-36)
6. Emotion Faces
7. Body Uneasiness Test – (BUT)
8. Social insecurity
9. Interpersonal distrust
1. (Lee et al., 2014)
2. (Ringel-Kulka et al., 2015)
3. (Choi et al., 2011; Fujimori et al., 2009; Lorenzo-Zuniga et al., 2014; Nobutani et al., 2017; Spiller et al., 2016)
4. (Bajaj et al., 2014)
5. (Pellino et al., 2013; Pinto-Sanchez et al., 2017)
6. (Tillisch et al., 2013)
7–9. (De Lorenzo et al., 2017)
1. Shoaling
2. Social novelty
3. Social interactions (including defeat)
1. (Borrelli et al., 2016)
2. (Guida et al., 2017)
3. (Arseneault-Breard et al., 2012; Bharwani et al., 2017; Buffington et al., 2016; D'Mello et al., 2015; Gilbert et al., 2013; Hsiao et al., 2013; Kantak et al., 2014; Tillmann et al., 2018)