Table 5.
Non-Human Trial Characteristics*.
| Species |
n Studies Reporting/n Total |
M | SD | Range | % Total |
|---|---|---|---|---|---|
| Age, days | |||||
| Rat | 16/25 | 109.7 | 162.0 | 2-660 | - |
| Mouse | 25/27 | 67.5 | 62.0 | 29-540 | - |
| Zebrafish | 2/5 | 77 | 103.2 | 4-180 | - |
| Quail | 1/1 | 6.5 | NA | NA | - |
| Animals in probiotic treatment arms, n | |||||
| Rat | 23/25 | 18.9 | 12.9 | 6-60 | - |
| Mouse | 21/27 | 20.2 | 12.0 | 6-49 | - |
| Zebrafish | 4/5 | 12.3 | 4.5 | 6-16 | - |
| Quail | 1/1 | 17 | NA | NA | - |
| Probiotic treatment duration, days | |||||
| Rat | 25/25 | 40.2 | 35.1 | 12-168 | - |
| Mouse | 27/27 | 28.3 | 21.2 | 5-84 | - |
| Zebrafish | 4/5 | 27.3 | 19.3 | 2-49 | - |
| Quail | 1/1 | 36 | NA | NA | - |
| Probiotic dosage, CFU | |||||
| Rat | 25/25 | 4.5 × 109 | 5.4 × 109 | 1.0 × 108 – 1.2 × 1010 | - |
| Mouse | 27/27 | 1.1 × 1010 | 2.2 × 1010 | 1.0 × 104 – 1.0 × 1011 | - |
| Zebrafish | 4/5 | 7.3 × 106 | 1.1 × 107 | 1.0 × 106 – 1.0 × 109 | - |
| Quail | 1/1 | 1.9 × 107 | NA | NA | - |
| Sex, % males | |||||
| Rat | 22/25 | - | - | - | 78.7 |
| Mouse | 20/27 | - | - | - | 87.0 |
| Zebrafish | 1/5 | - | - | - | 62.5§ |
| Quail | 1/1 | - | - | - | 0 |
*
Computed from studies reporting exact probiotic treatment group size, age, or numbers of animals by sex.
§
One out of five studies reported a total sample of 28 males. Three out of five studies reported using both males and females. One out of five studies did not report whether males or females were utilized.