Test Target condition	Studies	Participants (cases)	Sensitivity (95% CI) %	Specificity (95% CI) %
Detection of any metastasis
CT	4	1538 (913)	79.6 (76.0 to 82.8)	73.8 (51.5 to 88.2)
MRI	4	1556 (927)	76.4 (70.6 to 81.4)	83.0 (71.9 to 90.3)
Difference % (95% CI), P value			3.19 (‐3.25 to 9.64), P = 0.33	‐9.21 (‐30.1 to 11.7), P = 0.39
Detection of any metastasis
PET‐CT	4	962 (624)	93.2 (63.9 to 99.1)	88.8 (80.6 to 93.8)
CT	4	946 (609)	82.3 (76.6 to 86.9)	75.8 (58.9 to 87.2)
Difference % (95% CI), P value			10.9 (‐3.08 to 24.8), P = 0.13	13.0 (‐2.66 to 28.7), P = 0.10
Detection of any metastasis
PET‐CT	3	730 (473)	83.1 (65.3 to 92.8)	87.3 (76.7 to 93.5)
MRI	3	732 (472)	77.4 (70.6 to 82.9)	83.1 (72.9 to 90.0)
Difference % (95% CI), P value			5.79 (‐4.67 to 16.3), P = 0.28	4.20 (‐11.6 to 20.0), P = 0.60
Detection of nodal metastasis
CT	4	629 (348)	87.2 (76.5 to 93.4)	69.2 (34.6 to 90.5)
MRI	4	630 (348)	83.7 (68.8 to 92.3)	77.7 (72.4 to 82.1)
Difference % (95% CI), P value			3.41 (‐10.8 to 17.6), P = 0.64	‐8.45 (‐39.7 to 22.8), P = 0.60
Detection of nodal metastasis
PET‐CT	3	249 (156)	86.5 (80.2 to 91.1)	92.5 (85.0 to 96.4)
CT	3	250 (156)	89.0 (71.9 to 96.2)	74.5 (64.7 to 82.3)
Difference % (95% CI), P value			‐2.44 (‐14.9 to 10.0), P = 0.70	18.0 (7.69 to 28.3), P = 0.001
Detection of nodal metastasis
PET‐CT	3	249 (156)	86.5 (80.2 to 91.1)	92.5 (85.0 to 96.4)
MRI	3	251 (156)	86.1 (63.1 to 95.7)	78.9 (69.6 to 86.0)
Difference % (95% CI), P value			0.48 (‐15.8 to 16.8), P = 0.95	13.5 (3.73 to 23.3), P = 0.007
Detection of distant metastasis
CT	4	920 (571)	73.4 (63.6 to 81.3)	72.0 (64.3 to 78.5)
MRI	4	926 (579)	74.5 (62.1 to 83.9)	85.8 (70.4 to 93.9)
Difference % (95% CI), P value			‐1.10 (‐15.2 to 13.0), P = 0.88	‐13.9 (‐27.3 to ‐0.43), P = 0.043
Detection of distant metastasis
PET‐CT	3	481 (317)	81.8 (63.1 to 92.2)	83.5 (68.0 to 92.3)
CT	3	475 (308)	76.0 (62.6 to 85.7)	74.2 (61.9 to 83.6)
Difference % (95% CI), P value			5.77 (‐12.7 to 24.2), P = 0.54	9.35 (‐6.85 to 25.5), P = 0.26
Detection of distant metastasis
PET‐CT	3	481 (317)	81.8 (63.1 to 92.2)	83.5 (68.0 to 92.3)
MRI	3	481 (316)	77.0 (61.7 to 87.4)	83.8 (59.8 to 94.8)
Difference % (95% CI), P value			4.78 (‐14.6 to 24.1), P = 0.63	‐0.33 (‐21.1 to 20.4), P = 0.98