Table 2.
Association Between Viral Infection Subclasses and OPV3 Seroconversiona
| Infection Status by Pathogen | Infants, No. | Seropositive Infants, No. (%) | OR (95% CI) | P Value | P Value (Recently Acquired vs Persistent) |
|---|---|---|---|---|---|
| Adenovirus | |||||
| Absent | 507 | 269 (53.1) | … | … | … |
| Resolved | 74 | 45 (60.8) | 1.36 (.83–2.27) | .23 | … |
| Recently acquired | 88 | 40 (45.5) | 0.73 (.46–1.16) | .19 | … |
| Persistent | 35 | 13 (37.1) | 0.53 (.26–1.07) | .08 | .43 |
| Astrovirus | |||||
| Absent | 684 | 355 (51.9) | … | … | … |
| Resolved | 10 | 5 (50.0) | 1.10 (.30–4.05) | .89 | … |
| Recently acquired | 10 | 7 (70.0) | 2.30 (.58–10.81) | .24 | … |
| Persistent | 0 | … | … | … | … |
| Enterovirus | |||||
| Absent | 313 | 178 (56.9) | … | … | … |
| Resolved | 135 | 82 (60.7) | 1.24 (.82–1.90) | .30 | … |
| Recently acquired | 127 | 44 (34.6) | 0.38 (.25–.59) | <.001 | … |
| Persistent | 129 | 63 (48.8) | 0.70 (.46–1.06) | .09 | .02 |
| Norovirus | |||||
| Absent | 604 | 318 (52.6) | … | … | … |
| Resolved | 39 | 22 (56.4) | 1.18 (.61–2.32) | .62 | … |
| Recently acquired | 46 | 20 (43.5) | 0.70 (.38–1.28) | .25 | … |
| Persistent | 15 | 7 (46.7) | 0.67 (.23–1.89) | .44 | >.99 |
| Rotavirus | |||||
| Absent | 685 | 362 (52.8) | … | … | … |
| Resolved | 6 | 2 (33.3) | … | … | … |
| Recently acquired | 12 | 3 (25.0) | 0.34 (.07–1.16) | .11 | … |
| Persistent | 1 | 0 (0.0) | … | … | … |
| Sapovirus | |||||
| Absent | 671 | 348 (51.9) | … | … | … |
| Resolved | 15 | 8 (53.3) | 1.11 (.39–3.23) | .84 | … |
| Recently acquired | 16 | 9 (56.2) | 1.30 (.47–3.7) | .62 | … |
| Persistent | 2 | 2 (100.0) | … | … | … |
Abbreviations: CI, confidence interval; OPV3, type 3 oral poliovirus vaccine; OR, odds ratio.
aAge and study arm were included as covariates in all logistic regression models.