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. 2016 Jun 22;36(25):6742–6757. doi: 10.1523/JNEUROSCI.0011-16.2016

Figure 8.

Figure 8.

Synapsins influence the rate of quantal GABA release. A, Deconvolution analysis was used to determine rate of quantal release from average eIPSC waveforms. Left, Release rates for TWT and TKO neurons. Right, Same as left but scaled to the same maxima and superimposed. B, Integrals of release rate plots shown at left of A. C, Mean release rate constants for integrated release were determined for indicated genotypes. Release rate constants were prolonged in TKO neurons, as well as in TKO neurons expressing synapsin IIIa. D, Integrated amount of release for indicated isoforms. For C and D, asterisks indicate significant differences (p < 0.05) between TWT and TKO, determined by unpaired t test, and between TKO neurons expressing indicated synapsin isoforms, determined by ANOVA with Holm–Bonferroni post hoc test. E, Deconvolution analysis of release rates of TWT and TKO neurons, as well as TKO neurons expressing individual synapsin isoforms. Sample sizes for each group are as follows: TWT (14), TKO (14), synapsin Ia (15), synapsin Ib (25), synapsin IIa (14), synapsin IIb (17), and synapsin IIIa (19). F, Integrals of release calculated from traces in E.