Figure 5.

Effect of Cplx3/4 DKO on repetitive light stimulation. A, Response of a relatively dark-adapted horizontal cell from Cplx3/4 WT retina to repetitive full-field stimulation (15,000 lx, 1 Hz). B, Same as A but for Cplx3/4 DKO retina. C, Plot of peak and steady-state current amplitudes for horizontal cells from Cplx3/4 WT and Cplx3/4 DKO retinas. Peak and steady-state were determined as shown in Figure 4. Data points were fitted with a linear regression line (Cplx3/4 WT) and two monoexponential functions (Cplx3/4 DKO Peak, Cplx3/4 DKO steady-state). In horizontal cells from Cplx3/4 WT retina, no correlation was observed between current amplitude and stimulus number (Pearson r = 0.55083; R² = 0.07122). R² values for the monoexponential fits were 0.97765 and 0.96154 for peak and steady-state, respectively. Fitting a linear regression line to the steady-state data points resulted in a similar correlation coefficient (R² = 0.9486).