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. 2016 May 18;36(20):5608–5622. doi: 10.1523/JNEUROSCI.4261-15.2016

Figure 2.

Figure 2.

LCN2 upregulation in the glia after MPTP administration. A, Immunofluorescence staining of LCN2 in the striatum and SN of mouse brains at 24 h after MPTP treatment. Note that LCN2 expression is upregulated in both the striatum and SN of the MPTP-treated mouse. Scale bar, 50 μm. B, C, Colocalization of LCN2 expression with glial cells in the striatum (B) and SN (C) by double immunofluorescence staining. LCN2 (red) upregulation after MPTP administration is mainly localized within GFAP-positive astrocytes (green) in both the striatum and SN and partially in the Iba-1-positive microglia (green) at 24 h after injection. Scale bar, 50 μm. Arrows indicate colocalization of LCN2 and astrocytes/microglia.