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. 2016 Apr 13;36(15):4182–4195. doi: 10.1523/JNEUROSCI.4317-15.2016

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Copyright © 2016 the authors 0270-6474/16/364182-14$15.00/0

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Figure 4. — MC-21 antibody efficiently depletes circulating monocytes and MDMs in the brain. A, Numbers of circulating CCR2⁺ monocytes in sham-operated and stroke-subjected mice, injected with either vehicle or MC-21 antibody. Number of animals: Sham-vehicle, n = 9; MCAO-vehicle, n = 9; Day 4, n = 13; Day 7, n = 5; Day 10, n = 7; and Day 14, n = 8. Data are means ± SEMs; *p < 0.05, one-way ANOVA. B, Correlation graph showing CCR2⁺ circulating monocytes expressed as percentage of CD45^high/CD11b^high blood monocytes and MDMs expressed as percentage of all CD45⁺/CD11b⁺ macrophages in brains of stroke-subjected mice, injected with either vehicle or MC-21 antibody (n = 7). Correlation analysis, R² = 0.90, p < 0.05.