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. 2016 Apr 13;36(15):4182–4195. doi: 10.1523/JNEUROSCI.4317-15.2016

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Figure 8. — Proinflammatory and anti-inflammatory factors are expressed in the stroke-injured hemisphere. A–C, Quantitative PCR shows increased expression in the injured (ipsilateral) hemisphere of anti-inflammatory factor (Ym1) at 3 d (A), proinflammatory (IL-6, TNFα, IL-1β, NOS2) and anti-inflammatory (TGFβ1, Ym1, CXCL113, CCL22, CD163) factors at 7 d (B), and anti-inflammatory factors (TGFβ1, VCAM1) at 14 d (C) after stroke (n = 7). Data are means ± SEMs; *p < 0.05, unpaired t test. D, Fluorescence microscopic images of CXCR3–GFP⁺ chimeric mouse brain coronal sections showing double-immunostaining of MDMs (green) and IL-6, TGFβ, and BDNF (all red) at 3 and 7 d after stroke. Note the decreased immunoreactivity for IL-6 and increased staining for TGFβ and BDNF at 7 d compared with 3 d. Scale bar, 150 μm.