HRR modulates spiking activity in awake animals. A, Examples of juxtacellularly recorded discharges (top), respiration (Resp, blue) and DG LFP (black) for units coupled only to HRR (left), only to theta (θ, middle), or to both rhythms (right). B, Spike distribution over the phases of HRR (top) and of theta (bottom) for the same cells as in A. n.s., Not significant. C, D, Percentage of cells significantly coupled to either theta or HRR in CA1 and DG (C), and distribution of coupling selectivity (D). E, Average coupling strength to theta (black) and HRR (blue) for units recorded in CA1 and DG.