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Model for neuronal NMDAR-dependent control of radial glial filopodial motility. Neuronal NMDAR activation leads to NO production and diffusion to glia, where it stimulates the soluble guanylate cyclase (sGC) that elevates cGMP levels, activating PKG1. PKG1 regulates Rho family small GTPases, which control glial filopodial movement. Our data suggest that glial filopodial motility in turn participates in synapse formation and functional maturation.
