Table 1.
LS (50) | ES (40) | p-value | |
---|---|---|---|
RMP (mV) | −70.5 ± 0.6 | −65.6 ± 0.6 | <0.0001 |
Rheobase (pA) | 48.2 ± 2.6 | 34.3 ± 2.9 | 0.0005 |
Spike delay (ms) | 1721 ± 30 | 712 ± 70 | <0.0001 |
Ramp ratio | 1.28 ± 0.02 | 0.93 ± 0.01 | <0.0001 |
Input resistance (MΩ) | 363 ± 20 | 406 ± 24 | 0.18 |
Membrane time constant (ms) | 57.6 ± 5.3 | 57.2 ± 6.3 | 0.96 |
First AP threshold (mV) | −37.1 ± 0.6 | −37.8 ± 0.9 | 0.47 |
First AP max rising rate (V/s) | 232 ± 10 | 223 ± 12 | 0.65 |
First AP max falling rate (V/s) | 43.6 ± 1.4 | 45.6 ± 1.6 | 0.37 |
First AP half-width (ms) | 1.64 ± 0.03 | 1.53 ± 0.06 | 0.12 |
First AP height (mV) | 88.0 ± 1.3 | 89.6 ± 1.5 | 0.41 |
Second AP max rising rate (V/s) | 208 ± 12 | 195 ± 18 | 0.12 |
Second AP max falling rate (V/s) | 44.3 ± 2.5 | 43.2 ± 3.5 | 0.32 |
Second AP height (mV) | 79.9 ± 1.2 | 78.9 ± 1.3 | 0.97 |
Wilcoxon rank-sum test was performed to determine statistical significance between the groups. Numbers of cells are given in parentheses. All values are given as mean ± SEM.