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. 2016 May 4;36(18):4910–4916. doi: 10.1523/JNEUROSCI.3953-15.2016

Figure 3.

Figure 3.

The mGluR1 NAM, JNJ16259685 improves acute motor performance of 82Q mice. JNJ16259685 (0.03 mg/kg) restores (A) rotarod performance: *F(3,25) = 3.3, p = 0.03, two-way ANOVA; and (B) hindpaw base-of-support: *F(3,25) = 3.8, p = 0.02, two-way ANOVA, in 82Q but not WT mice, n = 7–8/group. C, JNJ16259685 (5 nm) reduces the amplitude (D) and duration (E) of 82Q but not WT mGluR1 currents: **F(1,9) = 19.9, p < 0.005; ***F(1,9) = 27, p < 0.001, n = 5 each group, two-way ANOVA. Symbols and error bars represent mean ± SEM.