Table 2.

Brain activation reflecting the additional sensitization in the uncontrollable pain condition

Brain region	Cluster size (no. of voxels)	Z-score peak	MNI peak coordinates (mm)
			x	y	z
Cluster spanning	1446	3.61	10	28	50
Supplementary motor area		3.61	10	28	50
ACC		3.59	10	22	32
		3.37	2	38	16
Cluster spanning	1011	3.74	46	20	−10
OFC		3.74	46	20	−10
Inferior frontal gyrus		3.65	50	20	−4
Frontal opercular cortex		3.64	44	20	0
Central opercular cortex (BA44)		3.46	54	8	0
Insula		3.26	44	10	−2
Cluster spanning	904	4.41	8	−84	−10
Visual cortex		4.41	8	−84	−10
Cluster spanning	507	3.69	−44	16	−2
Frontal opercular cortex		3.69	−44	16	−2
OFC		3.68	−32	20	−14
Insula		3.45	−38	10	0
Cluster spanning	455	3.71	4	−2	6
Thalamus		3.71	4	−2	6
Globus pallidus		3.34	14	0	2

Listed are brain areas in which activation was significant on a whole-brain level (voxel-based threshold Z > 2.3 and cluster-based threshold p < 0.05). Please note that local maxima are given as peaks if a significant cluster encompassed more than one region. ACC, anterior cingulate cortex; OFC, orbitofrontal cortex.