Figure 3.

D2R acts in parallel to rut-dependent cAMP signals. A, Three hour total memory was separated into consolidated ARM and labile ASM to test for genetic interactions between D2R, dnc-PDE4, and rut-AC1. B, C, Targeted knockdown of either dnc-PDE4 or rut-AC1 dissociated between ARM and ASM in a manner indistinguishable from appropriate mutants. D, Knockdown of rut-AC1, but not dnc-PDE4, resulted in loss of all memory phases, suggesting parallel processing of appropriate cAMP signals. E, Genetic controls performed on wild-type levels. Error bars indicate mean ± SEM of 6–8 biological repetitions (i.e., N = 6–8). Statistical differences at level of p ≤ 0.05 are denoted by different letters.