Table 2.

Synergistic effect of β-catenin and Notch1 double knockout on Sox²⁺ SCs proliferation and HCs generation

	Control (n =4)	β-cat-KO (n = 3)	Notch1-KO (n = 4)	β-cat-KO Notch1-KO (n = 3)
EdU+Sox2+ SCs/100 μm of sensory region
Apex	0	0	50 ± 2.52	0.67 ± 0.67
Mid	0	0	2.33 ± 0.33	0
Base	0	0	2.00 ± 1.16	0
EdU+Sox2+ SCs/100 μm of GER
Apex	0	0	39.67 ± 2/03	8.00 ± 1.73
Mid	0	0	4.67 ± 1.20	0.33 ± 0.33
Base	0	0	0	0
Sox2+ SCs/100 μm of sensory region
Apex	79.00 ± 2.08	81.00 ± 1.73	87.33 ± 3.93	50.67 ± 2.02
Mid	80.33 ± 2.60	75.33 ± 0.88	60.67 ± 3.28	65.33 ± 4.06
Base	70.67 ± 3.18	67.00 ± 3.21	72.00 ± 2.08	74.67 ± 0.88
EdU+Myo7a+ HCs/cochlea	0	0	18.50 ± 1.56	1.00 ± 0.58
Myo7a+ HCs/100 μm
Apex	57.33 ± 0.67	61.33 ± 0.88	132.67 ± 2.96	112.67 ± 13.86
Mid	56.33 ± 2.33	58.67 ± 0.33	67.00 ± 3.21	75.33 ± 2.67
Base	50.33 ± 3.18	49.00 ± 1.15	52.67 ± 1.33	57.00 ± 1.53